Trichodermin (4β-acetoxy-12,13-epoxytrichothec-9-ene)
نویسندگان
چکیده
In the title natural product, C(17)H(24)O(4), which is a very potent inhibitor of protein synthesis in mammalian cells, the five-membered ring displays an envelope conformation, whereas the two six-membered rings show different conformations, viz. chair and half-chair.
منابع مشابه
Dihalogenated trichodermin (4β-acetoxy-9,10-dibromo-12,13-epoxytrichothec)
In the title dihalogenated trichodermin mol-ecule, C(17)H(24)Br(2)O(4) (systematic name: 9,10-dibromo-12,13-epoxy-trichothec-9-en-4β-yl acetate), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show the same conformation, viz. chair. As for the seven-membered ring, the dihedral angle between the mean planes formed by the four C atoms of the envelope ...
متن کاملTrichodermin (12,13-epoxytrichethec-9-en-4β-yl 4-fluorobenzoate)
IN THE TITLE TRICHODERMIN COMPOUND (SYSTEMATIC NAME: 12,13-ep-oxy-trichothec-9-en-4β-yl 4-fluoro-benzoate), C(22)H(25)FO(4), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show the different conformations, viz. chair and half-chair. As for the seven-membered ring, the dihedral angle between the mean planes formed by the four C atoms of the envelope ...
متن کاملAntifungal activity of metabolites of the endophytic fungus Trichoderma brevicompactum from garlic
The endophytic fungus strain 0248, isolated from garlic, was identified as Trichoderma brevicompactum based on morphological characteristics and the nucleotide sequences of ITS1-5.8S- ITS2 and tef1. The bioactive compound T2 was isolated from the culture extracts of this fungus by bioactivity-guided fractionation and identified as 4β-acetoxy-12,13- epoxy-Δ(9)-trichothecene (trichodermin) by spe...
متن کاملEffects of Trichothecene Production on the Plant Defense Response and Fungal Physiology: Overexpression of the Trichoderma arundinaceum tri4 Gene in T. harzianum.
Trichothecenes are fungal sesquiterpenoid compounds, the majority of which have phytotoxic activity. They contaminate food and feed stocks, resulting in potential harm to animals and human beings. Trichoderma brevicompactum and T. arundinaceum produce trichodermin and harzianum A (HA), respectively, two trichothecenes that show different bioactive properties. Both compounds have remarkable anti...
متن کاملTrichodermol (4α-hydroxy-12,13-epoxytrichothec-9-ene)
In the title compound, C(15)H(22)O(3), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show different conformations, viz. chair and half-chair. In the crystal, mol-ecules are linked through inter-molecular O-H⋯O hydrogen bonds, forming chains running along the b axis.
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عنوان ژورنال:
دوره 64 شماره
صفحات -
تاریخ انتشار 2008